Researcher Profile

I am currently working on functional T and B cell studies in understanding the immunological basis of cholera infections in Bangladesh and related to protection. My main research interests focus on characterization of antigen specific single cells in blood and mucosa to better understand cholera pathology by using cutting edge research nanotechnology and flow cytometry.

My  major  interest  in  the  last  few  years  has  been  made  in  microbiology  and immunology  of  infectious  diseases  in  developing  countries  especially  to  enteric infections,  eg. Vibrio  cholerae,  enterotoxigenic Escherichia  coli, and Helicobacter pylori.  I  am  currently  working  on  functional  T  cell  studies  in  understanding  the immunological basis of different enteric infections in Bangladesh and protection.  

My  research  is  focuses  on  for  understanding  of  cellular and  adaptive  immunity  in children as well as in adults. The major goal of these studies is to       understand the T-B cell interaction, and the type of T cells that are mainly responsible for B cell help.  

I  am  also  involved  with  cholera  (Shanchol)  vaccine  clinical trial,  where  we  are evaluating  humoral  and  adaptive  immune  responses  in  different  age  groups  of participants of Bangladesh.

- We have particular interest to study mucosal and systemic immune responses to enterotoxigenic Escherchia coli infection and relation to protection, that includes evaluating if ETEC diarrhea induces antigen specific acute B and T cell responses as well as memory responses which are long lasting.

- Another important area has been made is in the development of diagnostic tests for detection of H. pylori antigens. As the incidence of H. pylori infection is very high in these endemic settings, this has been extremely important to diagnose this infection in children and adults. In addition, we are also evaluating the immune responses in developing countries and how much this is differing from developed countries.  

Selected publications include:

• Bhuiyan TR, Hoq MR, Nishat NS, Al Mahbuba D, Rashu R, Islam K, Hossain L, Dey A, Harris JB, Ryan ET, Calderwood SB, Svennerholm AM, Qadri F. Enumeration of gut-homing β7-positive, pathogen-specific antibody secreting cells in whole blood in enterotoxigenic Escherichia coli and Vibrio cholerae-infected patients using an ELISPOT technique. Clin Vaccine Immunol. 2015 Oct 28. pii: CVI.00526-15. PMID: 26512047
• Qadri F, Ali M, Chowdhury F, Khan AI, Saha A, Khan IA, Begum YA, Bhuiyan TR, Chowdhury MI, Uddin MJ, Khan JA, Chowdhury AI, Rahman A, Siddique SA, Asaduzzaman M, Akter A, Khan A, Ae You Y, Siddik AU, Saha NC, Kabir A, Riaz BK, Biswas SK, Begum F, Unicomb L, Luby SP, Cravioto A, Clemens JD. Feasibility and effectiveness of oral cholera vaccine in an urban endemic setting in Bangladesh: a cluster randomised open-label trial. Lancet. 2015 Oct 3;386(10001):1362-71. PMID: 26164097
• Leung DT, Bhuiyan TR, Nishat NS, Hoq MR, Aktar A, Rahman MA, Uddin T, Khan AI, Chowdhury F, Charles RC, Harris JB, Calderwood SB, Qadri F, Ryan ET. Circulating mucosal associated invariant T cells are activated in Vibrio cholerae O1 infection and associated with lipopolysaccharide antibody responses. PLoS Negl Trop Dis. 2014 Aug 21;8(8):e3076. PMID: 25144724
• Taufiqur  R  Bhuiyan, MM Towhidul Islam, Taher Uddin, Mohiul I  Chowdhury,  Anders Janzon,  Jenni  Adamsson,  Samuel  B  Lundin,  Firdausi  Qadri,  Anna  Lundgren.  Th1  and Th17  responses  to Helicobacter  pylori  in  Bangladeshi  infants,  children  and  adults. Accepted in Plos One, Apr 8;9(4):e93943 PMID: 24714675
• Taufiqur R Bhuiyan, Feroza K Choudhury,Farhana Khanam, Amit Saha, Md. Abu Sayeed, Umme Salma, Anna Lundgren, David A Sack, Ann-Mari Svennerholm, Firdausi Qadri. Evaluation of immune responses to an oral typhoid vaccine, Ty21a, in children from two to five years of age in Bangladesh. Vaccine. 2014 Feb 19;32(9):1055-60, PMID: 24440210
• Rahman A, Rashu R, Bhuiyan  TR, Chowdhury F, Khan AI, Islam K, Larocque RC, Ryan ET, Wrammert J, Calderwood SB, Qadri F, Harris JB. Antibody-Secreting Cell Responses after   Vibrio  cholerae  O1  Infection  and   Oral   Cholera   Vaccination  in   Adults  in Bangladesh. Clin Vaccine Immunol. 2013 Oct;20(10):1592-8. Epub 2013 Aug 14.
• Taufiqur Rahman Bhuiyan, Amit Saha, Anna Lundgren, Firdausi Qadri, Ann-Mari Svennerholm. Immune responses to Helicobacter pylori infection in Bangladeshi children during their first two years of life and relation between maternal antibodies and onset of infection. J Infect Dis. 2010 Dec 1;202(11):1676-84.
• Bhuiyan TR, Lundin SB, Khan AI, Lundgren A, Harris JB, Calderwood SB, Qadri F. Cholera caused by Vibrio cholerae O1 induces T-cell responses in the circulation. Infect Immun. 2009 Feb 23: 1888-1893
• Bhuiyan TR, Qadri F, Saha A, Svennerholm AM. Infection by Helicobacter pylori in Bangladeshi children from birth to two years: relation to blood group, nutritional status and seasonality. Pediatr Infect Dis J. 2009 Feb 28 (2): 79-85.
• Bhuiyan TR, Qadri F, Bardhan PK, Ahmad MM, Kindlund B, Svennerholm AM, Lundgren A. Comparison of mucosal B- and T-cell responses in Helicobacter pylori-infected subjects in a developing and a developed country. FEMS Immunol Med Microbiol. 2008 Oct; 54(1):70-9.