Researcher Profile

My own research over the past 30 years has focused primarily on the pathophysiology, diagnosis and management of acute and persistent diarrhoea and dehydration in children and adults, particularly in poor countries. My main focus of research is further improvement of oral rehydration solution, finding an effective antidiarrhoeal drugs/food and appropriate procedure of rehydration in severely malnourished children especially severe acute malnutrition (SAM). I have over 70 publications in peer-reviewed journals, including several seminal publications on the use of oral rehydration solution for the management of cholera and non-cholera diarrhea.

Selected publications include:

• Alam NH, Ashraf H, Kamruzzaman M, Ahmed T, Islam S, Olesen MK, Gyr N, Meier R. Efficacy of partially hydrolyzed guar gum (PHGG) supplemented modified oral rehydration solution in the treatment of severely malnourished children with watery diarrhoea: a randomised double-blindcontrolled trial.J Health Popul Nutr. 2015 May 1:34(1):3 doi: 10.1186/s41043-0
• Sarker SA, Jäkel M, Sultana S, Alam NH, Bardhan PK, Chisti MJ, Salam MA, Theis W, Hammarström L, Frenken LG. Anti-rotavirus protein reduces stool output in infants with diarrhea: a randomized placebo-controlled trial.Gastroenterology. 2013 Oct;145(4):740-748.e8. doi: 10.1053/j.gastro.2013.06.053. Epub 2013 Jul 2.
• Alam NH, Ashraf H, Olesen M, Salam MA, Gyr N, Meier R. Salovum egg yolk containing antisecretory factor as an adjunct therapy in severe cholera in adult males: a pilot study.J Health Popul Nutr. 2011 Aug;29(4):297-302.
• Alam NH, Raqib R, Ashraf H, Qadri F, Ahmed S, Zasloff M, Agerberth B, Salam MA, Gyr N, Meier R. L-isoleucine-supplemented oral rehydration solution in the treatment of acute diarrhoea in children: a randomized controlled trial.Health Popul Nutr. 2011 Jun;29(3):183-90.
• Alam NH,Islam S, Sattar S,Monira S, Desjeux JF. The safety of rapid intravenous rehydration and comparative efficacy of three oral rehydration solutions in the treatment of severely malnourished hildren with dehydrating cholera J Pediatr Gastro Nutr 2009;48:318-27.
• Alam NH,Raqib R, Ashraf H, Qadri F, Ahmed S, Zasloff M, Agerberth B, Salam MA, Gyr N, Meier R. L-isoleucine supplemented oral rehydration solution in acute diarrhea in children: a randomized controlled trial  J Health Popul Nutr 201129:297-302
• Alam NH, M Yunus, A S G Faruque, N Gyr, MA Salam, D A Sack. Symptomatic hyponatremia during treatment of dehydrating diarrheal disease with reduced osmolarity oral rehydration solution JAMA 2006;296:567-573.
• Alam NH,Hamadani JD, Dewan N, Fuchs GJ. Efficacy and safety of a modified oral rehydration solution (ReSoMaL) in the treatment of severely malnoursished children with watery diarrhoea. J Pediatr 2003;143:614-9.
• Alam NH, Majumder RN, Fuchs GJ and Choice study group. Efficacy and safety of oral rehydration solution with reduced osmolarity in adults with cholera: a randomized double-blind clinical trial The Lancet 1999; 354:293-9.
• Alam NH, Bardhan PK, Haider R, Mahalanabis D. Trimethoprim-sulphamethoxazole  in the treatment of persistent diarrhoea: a double blind placebo controlled clinical trial. Arch Dis Child 1995;72(6):483-6.